The boundary wall of the Softgel capsule is always soft and flexible as compared to hard gelatin, which is rigid and firm.Look at the table below to understand hard gelatin capsules sizes: This does not apply for Softgel capsules. Hard gelatin capsules sizes are available as 0, 1, 2, 3, 4, and 6.This is because the hard gelatin capsules are unable to deal with the oily, liquid, and even semisolid preparations. It is easier to encapsulate liquid, oily, and even semisolid preparations in Softgel capsules compared to the hard gelatin capsules.Disintegration of the hard gelatin capsule is less as compared to that of Softgel capsules.The procedures involved in medicament filling is more complicated in Softgel when compared to hard gelatin capsules.This is done to prevent the medicines from coming out as a result of rough handling of the drugs. The sealing of the hard gelatin capsule is accomplished after the filling is done. Sealing of Softgel capsules is done in combined operation on the machine.This, therefore, makes the consumption of gelatin and plasticizers to be higher in Softgel capsules as compared to hard gelatin capsules. In Softgel, the ratio is 0.8:1 while in hard gelatin capsule it is 0.4:1. The ration of gelatin to plasticizer is more in a Softgel capsule as compared to the hard gelatin capsule.On the other hand, the shell of the hard gelatin is composed of titanium dioxide, plasticizers as well as coloring agents. Shell of the Softgel capsule is composed of plasticizers, gelatin, sugars, opacifying agents, preservatives gelatin, and even coloring agents.Softgel capsules come in various shapes like oval, round and even in the form of tube-like shapes.The hard gelatin medicine is as well composed of a cap and a body. Hard gelatin capsule, on the other hand, has its shell filled with powder or tiny pellet medicine. Softgel capsule is a liquid filled medicine and sealed hermetically as a single piece.Let us, thus, discuss some of the significant differences that exist between the two drugs. soft gelatin capsulesįrom the above definition of the capsules, there are many differences between the Softgel capsule and the hard gelatin capsule.ĭifferences can be in the physical attributes of the capsules or their purposes. They are both used in the pharmaceutical industry as medicines and also made from gelatin compounds. On the other hand, hard gelatin capsules have casings that are mainly composed of very tiny pellets or even powder medicine. Softgel capsule is a type of medicine whose shell is mostly composed of liquid substances which are readily soluble. Differences between Softgel Capsules and Hard Gelatin Capsules The cost of production rises due to the specialized technology needed during the production of the capsules. The cost of producing the capsule is relatively high.īesides, the impact is immense on the manufacturers who used to make traditional tablets. Compatibility with carriers or excipient with gelatin is still limited to few choices. Manufacturing of softgel capsules needs specialized equipment. The stability and development of the shell life of the capsule are faced with many challenges due to the dynamic nature of the capsule.Ĭare should as well be taken during transportation as well as storage as they are always more sensitive to hot weathers. It provides ultra-low doses of compounds, making them reduce the melting point of the designated compounds.ĭust in the manufacturing industries is also reduced during the generation of the doses, which improves the safety of the production personnel. This is possible in the case of poorly soluble solid doses. It delivers matrix liquid that is meant to dissolve to improve the solubility of the oral bioavailability. The softgel capsule provides various advantages due to its property. The drugs, therefore, have lower permeability and aqueous solubility. This is reinforced with the fact that the current drugs discovered are poorly biopharmaceutical. The capsule is, therefore, of growing interest for oral delivery in doses which are poorly soluble in water. It readily dissolves in the gastric juices and other stomach liquids as compared to other capsules. It can, therefore, dissolve quickly as compared to a hard gelatin capsule. In fact, they form the main ingredients of soft gelatin capsules. The shell of the softgel capsule is a combination of a pacifier, water, gelatin, as well as plasticizers like the sorbitol or even glycerin. The capsule is composed of a shell consisting of gelatin that covers the liquid filled in the capsule. Softgel capsule resembles the ordinary capsules, however, the manufacturing process is quite different. Factors Determining Softgel Shapes and Sizes.Differences between Softgel Capsules and Hard Gelatin Capsules.
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